Moderated by Jordan Gutterman, M. Lasker Award winner David Allis of Rockefeller University discussed the importance of choosing the right lab environment. He spoke about how he mentors and supports the people in his lab and how each of the laureates at the table hold that standard. The importance of quality mentorship and serendipity was emphasized by Lasker Award winner Joan Steitz who spoke about her early years working with an outstanding mentor and previous Lasker Laurette Dr.
The history of oxygen sensing: 2016 Lasker Award for Basic Medical Research
Calendar of events, awards and opportunities
The importance of adequate oxygenation has been known for a long time. Oxygen has been early recognized as a critical substrate for cell metabolism: mitochondrial oxidative phosphorylation, which consumes oxygen, is up to 15 times more efficient in ATP production than anaerobic glycolysis. However, how animals sense and adapt to changes in oxygen availability have remained a big enigma until when the research of Drs. William Kaelin, Peter Ratcliffe and Gregg Semenza has allowed the discovery of the molecular mechanisms underlying cellular adaptive response to low levels of oxygen, condition known as hypoxia see the timeline below. For this great contribution to medical science, they have been awarded the Albert Lasker Basic Medical Research Award. One of the first strong evidence for a mechanism of oxygen sensing in animals was provided by the discovery of erythropoietin EPO , a glycoprotein hormone produced by the fetal liver and then the adult kidney which stimulates erythrocyte production in response to low blood oxygen levels.
A 7-month-old baby in Belgium tragically died as a result of the strict diet his parents fed him, which exclusively consisted of gluten-free and lactose-free foods, as well as quinoa milk. In court, Lucas' parents claimed that they never took him to a doctor because they didn't notice that anything was seriously wrong with their child. His mother added that sometimes Lucas would gain a little weight and then lose it, which she thought was natural. Eventually, the pair did take the child to a homeopathic doctor, who insisted they take him to a real hospital after observing the child's condition. The 7 month old weighed just 9.
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